Ved langvarig brug er der risiko for misbrug og afhængighed og særligt ved høje doser for kognitive bivirkninger og endokrine og immunologiske bivirkninger.defineres som smerter, der er forårsaget af en skade eller sygdom, som afficerer det somatosensoriske nervesystem. Neuropatiske smerter kan skyldes beskadigelse af nervebanerne på ethvert s
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